Water & Scutellaria Baicalensis Root Extract & Astragalus Membranaceus Root Extract & Rehmannia Glutinosa Root Extract & Magnolia Officinalis Bark Extract & Pentylene Glycol & Propanediol & Phenethyl Alcohol
Volugro BCR is a complex of botanical extracts chosen to create “an invisible helmet” to promote the health and wellness of the scalp. Each extract plays a synergistic role in nourishing the scalp and creating a proper environment to encourage hair fullness and reduce the occurrence of hair-fall.
Scutellaria Baicalensis is commonly known as skullcap or helmet flower, alluding to its resemblance to miniature medieval helmets. It is an important herb in traditional Chinese medicine (TCM), and baicalin, the active flavonoid isolated from the plant, is known for many biological activities, including anti-inflammatory and antioxidant properties. Studies report that baicalin promotes the growth of ex-vivo cultured human hair follicles and stimulates the secretion of vascular endothelial growth factor (VEGF). VEGF is a major mediator of hair follicle growth and cycling, and provides the first direct evidence that improved follicle vascularization promotes hair health growth and increases the size of both the follicle and the hair fiber.
The hair follicle is comprised of epidermal and dermal compartments, whose reciprocal interactions are considered to be key regulators of hair follicle development and the hair cycle. Although the communication between these compartments is complex, dermal papilla cells are thought to be the inducers, and epidermal cells to be the responders in hair follicle formation and the hair cycle. Baicalin has been reported to activate the Wnt/β-catenin signaling pathway and increase activity that facilitates dermal papilla cell differentiation. These are crucial components in nourishing hair and allowing for growth.
The specific combination of Astragalus Membranaceus and Rehmannia Glutinosa has been shown to upregulate the synthesis of TGF-b1, which is important both for the regulation of the triphasic hair growth cycle and helping cell intercommunication. Astragaloside (a major triterpene saponin extracted from Astragalus) inhibits apoptosis in hair keratinocytes, and retards spontaneous catagen induction, resulting in the promotion of hair regrowth. Apoptosis with premature termination of hair follicle growth induces several types of hair loss and is one of the crucial factors of hair loss. The water extract of Rehmannia Glutinosa also has high free radical scavenging activity in vitro and decreases the level of intracellular ROS. The major chemical constituents of the herb, polysaccharides and iridoid monoterpenes, have been demonstrated to suppress inflammatory responses elicited by advanced glycation end products (antiAGE activity).
A chemical investigation of the cortex of Magnolia Officinalis (Magnolia bark extract) reveals several major lignans such as honokiol and magnolol, which have notable anti-inflammatory properties and benefits focused on TGF-B cell cycle arrest to decrease hair loss.
In vitro testing shows that Volugro BCR downregulates the expression of proteins destructive to the extracellular matrix (MMP-1) and upregulates an essential protein in the basement membrane (LAMA-1) as well as two important cellular growth factors (TGF-β and VEGF). This activity helps to support cellular function and communication, and nutrition of the scalp skin cells to prevent aging and hair loss.