Activen XEP™-018

The Story

Activen XEP™-018 is a biomimetic of a natural conopeptide from venomous marine cone snail (Conus consors).  Biologically, it acts as a modulator of the neuromuscular transmission, as well as a potent and selective blocker of the voltage-gated sodium channel Nav 1.4.  Cosmetically, it acts as an instant line relaxer giving a smooth skin appearance.

The Technology

Biotechnology to create 2.0 active ingredient generation

The Biology
Mechanism of Action

How does XEP™-018 generate wrinkle relaxing?



Benefits for Cosmetic Applications:


  • Decrease Surface-Length-Depth of Wrinkles When Smiling
  • Visible Crow’s Feet Line Smoothing
  • Eyelid Opening

Technical Data:
Crow's Feet Wrinkles & Rugosity

In vivo study of a single application with 3% XEP™-018 on 33 subjects results in visible and significant reduction of wrinkle depth and rugosity 2 hours after application.



*Additional clinical data available upon request


  • INCI: Mu-conotoxin CnIIIC
  • Suggested use level is 1-5% in skin care formulations.  Can be used up to 25%.
  • Clear, Colorless, Odorless
  • Add at the end of the formulation at 30°C.